Career Objective: | Full-time permanent position as bioinformatician/software developer.. |
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Education: | University
of North Carolina at Chapel Hill B.S. Mathematical Sciences - Computer Science Option, Minor in Physics. May 1996. |
Experience: |
Bioinformatics
Scientist: Bioinfomatics Core, UNC Lineberger Comprehensive
Cancer Center, UNC-CH, Chapel Hill, NC, October 2016 to
present. Application
Specialist: Bioinfomatics Core, UNC Lineberger Comprehensive
Cancer Center, UNC-CH, Chapel Hill, NC, July 2009 to
September 2016. Application
Analyst: ITS Teaching and Learning, Teaching and Learning
Interactive, UNC-CH, Chapel Hill, NC, August 2006 to
July 2009. Application
Programmer: ITS Enterprise Applications, Student Information
Services, UNC-CH, Chapel Hill, NC, September 2004 to
August 2006. Application
Programmer: AIS Student Information Services, UNC-CH, Chapel
Hill, NC, November 2001 to September 2004. Application
Programmer: ATN Instructional Technology Development, UNC-CH,
Chapel Hill, NC, March 1998 to November 2001. Consultant:
OIT Technical Assistance Center, UNC-CH, Chapel Hill, NC, October 1994
to March 1998. Demonstrator: Magic Shop,
Busch Gardens, Williamsburg, VA, June to August 1993. |
Skills: | Languages: Perl, Python, Nextflow (Groovy), SQL,
Unix shell scripts, R, HTML, Javascript, Java, CWL, PL/SQL.
Bioinformatics tools: GATK, ABRA, BWA, SAMtools, BEDtools, STAR, Salmon, MultiQC, IGV, Picard, BCL2Fastq, BCL Convert. Server Operating Systems: CentOS, RHEL. Server Applications: SLURM, Docker, SunGridEngine, Oracle, MySQL. Desktop Operating Systems: macOS, GNU/Linux (Ubuntu, CentOS), Windows. Desktop Applications: VSCode, Emacs, vi, SQLDeveloper, IntelliJ, git. Cloud Platforms: Google Compute Platform, Amazon AWS, Arvados, GitHub, GitLab, Dockerhub |
Publications: | Authorship noted in bold, Publication Titles are underlined Eric D. Routh, Amanda E. D. Van Swearingen, Maria J. Sambade, Steven Vensko, Marni B. McClure, Mark G. Woodcock, Shengjie Chai, Luz A. Cuaboy, Amy Wheless, Amy Garrett, Lisa A. Carey, Alan P. Hoyle, Joel S. Parker, Benjamin G. Vincent and Carey K. Anders Comprehensive Analysis of the Immunogenomics of Triple-Negative Breast Cancer Brain Metastases From LCCC1419Front. Oncol., 27 July 2022, https://doi.org/10.3389/fonc.2022.818693 Paul Little, Heejoon Jo, Alan Hoyle, Angela Mazul, Xiaobei Zhao, Ashley H Salazar, Douglas Farquhar, Siddharth Sheth, Maheer Masood, Michele C Hayward, Joel S Parker, Katherine A Hoadley, Jose Zevallos, D Neil Hayes, UNMASC: tumor-only variant calling with unmatched normal controls, NAR Cancer, Volume 3, Issue 4, December 2021, zcab040, https://doi.org/10.1093/narcan/zcab040 Travis P. Schrank MD, PhD, Nicholas Lenze MPH, Lee P. Landess, Alan Hoyle, Joel Parker PhD, Asim Lal, Siddharth Sheth MD, Bhishamjit S. Chera MD, Samip N. Patel MD, Trevor G. Hackman MD, M. Ben Major PhD, Natalia Issaeva PhD, Wendell G. Yarbrough MD Genomic heterogeneity and copy number variant burden are associated with poor recurrence‐free survival and 11q loss in human papillomavirus‐positive squamous cell carcinoma of the oropharynx, Cancer (2021), https://doi.org/10.1002/cncr.33504 Campbell, P.J., Getz, G., Korbel, J.O. et al. Pan-cancer analysis of whole genomes. Nature 578, 82–93 (2020). https://doi.org/10.1038/s41586-020-1969-6 Marni B. Siegel, Xiaping He, Katherine A. Hoadley, Alan Hoyle, Julia B. Pearce, Amy L. Garrett, Sunil Kumar, Vincent J. Moylan, Claudia M. Brady, Amanda E.D. Van Swearingen, David Marron, Gaorav P. Gupta, Leigh B. Thorne, Niamh Kieran, Chad Livasy, Elaine R. Mardis, Joel S. Parker, Mengjie Chen, Carey K. Anders, Lisa A. Carey, Charles M. Perou. Integrated RNA and DNA sequencing reveals early drivers of metastatic breast cancer, J Clin Invest. 2018;128(4):1371-1383. https://doi.org/10.1172/JCI96153. Patel NM, Michelini VV, Snell JM, Balu S, Hoyle AP, Parker JS, Hayward MC, Eberhard DA, Salazar AH, McNeillie P, Xu J, Huettner CS, Koyama T, Utro F, Rhrissorrakrai K, Norel R, Bilal E, Royyuru A, Parida L, Earp HS, Grilley-Olson JE, Hayes DN, Harvey SJ, Sharpless NE, Kim WY. Enhancing Next-Generation Sequencing-Guided Cancer Care Through Cognitive Computing. The Oncologist. theoncologist.2017-0170. doi: 10.1634/theoncologist.2017-0170. The Oncologist February 2018 vol. 23 no. 2 179-185 PMID: 29158372 Campbell JD, Alexandrov A, Kim J, Wala J, Berger AH, Pedamallu CS, Shukla SA, Guo G, Brooks AN, Murray BA, Imielinski M, Hu X, Ling S, Akbani R, Rosenberg M, Cibulskis C, Ramachandran A, Collisson EA, Kwiatkowski DJ, Lawrence MS, Weinstein JN, Verhaak RG, Wu CJ, Hammerman PS, Cherniack AD, Getz G; Cancer Genome Atlas Research Network, Artyomov MN, Schreiber R, Govindan R, Meyerson M. "Distinct patterns of somatic genome alterations in lung adenocarcinomas and squamous cell carcinomas." Nat Genet. 2016 Jun;48(6):607-16. doi: 10.1038/ng.3564. Epub 2016 May 9. Seifert BA, O'Daniel JM, Amin K, Marchuk DS, Patel NM, Parker JS, Hoyle AP, Mose LE, Marron A, Hayward MC, Bizon C, Wilhelmsen KC, Evans JP, Earp HS, Sharpless N, Hayes DN, Berg JS. "Germline Analysis from Tumor-Germline Sequencing Dyads to identify clinically actionable secondary findings." Clin Cancer Res. 2016 Apr 15. pii: clincanres.0015.2016. [Epub ahead of print] Ceccarelli M, Barthel FP, Malta TM, Sabedot TS, Salama SR, Murray BA, Morozova O, Newton Y, Radenbaugh A, Pagnotta SM, Anjum S, Wang J, Manyam G, Zoppoli P, Ling S, Rao AA, Grifford M, Cherniack AD, Zhang H, Poisson L, Carlotti CG Jr, Tirapelli DP, Rao A, Mikkelsen T, Lau CC, Yung WK, Rabadan R, Huse J, Brat DJ, Lehman NL, Barnholtz-Sloan JS, Zheng S, Hess K, Rao G, Meyerson M, Beroukhim R, Cooper L, Akbani R, Wrensch M, Haussler D, Aldape KD, Laird PW, Gutmann DH; TCGA Research Network, Noushmehr H, Iavarone A, Verhaak RG. "Molecular Profiling Reveals Biologically Discrete Subsets and Pathways of Progression in Diffuse Glioma." Cell. 2016 Jan 28;164(3):550-63. doi: 10.1016/j.cell.2015.12.028. Cancer Genome Atlas Research Network. "The Molecular Taxonomy of Primary Prostate Cancer." Cell. 2015 Nov 5;163(4):1011-25. doi: 10.1016/j.cell.2015.10.025. Cancer Genome Atlas Research Network, Linehan WM, Spellman PT, Ricketts CJ, Creighton CJ, Fei SS, Davis C, Wheeler DA, Murray BA, Schmidt L, Vocke CD, Peto M, Al Mamun AA, Shinbrot E, Sethi A, Brooks S, Rathmell WK, Brooks AN, Hoadley KA, Robertson AG, Brooks D, Bowlby R, Sadeghi S, Shen H, Weisenberger DJ, Bootwalla M, Baylin SB, Laird PW, Cherniack AD, Saksena G, Haake S, Li J, Liang H, Lu Y, Mills GB, Akbani R, Leiserson MD, Raphael BJ, Anur P, Bottaro D, Albiges L, Barnabas N, Choueiri TK, Czerniak B, Godwin AK, Hakimi AA, Ho TH, Hsieh J, Ittmann M, Kim WY, Krishnan B, Merino MJ, Mills Shaw KR, Reuter VE, Reznik E, Shelley CS, Shuch B, Signoretti S, Srinivasan R, Tamboli P, Thomas G, Tickoo S, Burnett K, Crain D, Gardner J, Lau K, Mallery D, Morris S, Paulauskis JD, Penny RJ, Shelton C, Shelton WT, Sherman M, Thompson E, Yena P, Avedon MT, Bowen J, Gastier-Foster JM, Gerken M, Leraas KM, Lichtenberg TM, Ramirez NC, Santos T, Wise L, Zmuda E, Demchok JA, Felau I, Hutter CM, Sheth M, Sofia HJ, Tarnuzzer R, Wang Z, Yang L, Zenklusen JC, Zhang J, Ayala B, Baboud J, Chudamani S, Liu J, Lolla L, Naresh R, Pihl T, Sun Q, Wan Y, Wu Y, Ally A, Balasundaram M, Balu S, Beroukhim R, Bodenheimer T, Buhay C, Butterfield YS, Carlsen R, Carter SL, Chao H, Chuah E, Clarke A, Covington KR, Dahdouli M, Dewal N, Dhalla N, Doddapaneni HV, Drummond JA, Gabriel SB, Gibbs RA, Guin R, Hale W, Hawes A, Hayes DN, Holt RA, Hoyle AP, Jefferys SR, Jones SJ, Jones CD, Kalra D, Kovar C, Lewis L, Li J, Ma Y, Marra MA, Mayo M, Meng S, Meyerson M, Mieczkowski PA, Moore RA, Morton D, Mose LE, Mungall AJ, Muzny D, Parker JS, Perou CM, Roach J, Schein JE, Schumacher SE, Shi Y, Simons JV, Sipahimalani P, Skelly T, Soloway MG, Sougnez C, Tam A, Tan D, Thiessen N, Veluvolu U, Wang M, Wilkerson MD, Wong T, Wu J, Xi L, Zhou J, Bedford J, Chen F, Fu Y, Gerstein M, Haussler D, Kasaian K, Lai P, Ling S, Radenbaugh A, Van Den Berg D, Weinstein JN, Zhu J, Albert M, Alexopoulou I, Andersen JJ, Auman JT, Bartlett J, Bastacky S, Bergsten J, Blute ML, Boice L, Bollag RJ, Boyd J, Castle E, Chen YB, Cheville JC, Curley E, Davies B, DeVolk A, Dhir R, Dike L, Eckman J, Engel J, Harr J, Hrebinko R, Huang M, Huelsenbeck-Dill L, Iacocca M, Jacobs B, Lobis M, Maranchie JK, McMeekin S, Myers J, Nelson J, Parfitt J, Parwani A, Petrelli N, Rabeno B, Roy S, Salner AL, Slaton J, Stanton M, Thompson RH, Thorne L, Tucker K, Weinberger PM, Winemiller C, Zach LA, Zuna R. "Comprehensive Molecular Characterization of Papillary Renal-Cell Carcinoma." N Engl J Med. 2016 Jan 14;374(2):135-45. doi: 10.1056/NEJMoa1505917. Epub 2015 Nov 4. Ciriello G, Gatza ML, Beck AH, Wilkerson MD, Rhie SK, Pastore A, Zhang H, McLellan M, Yau C, Kandoth C, Bowlby R, Shen H, Hayat S, Fieldhouse R, Lester SC, Tse GM, Factor RE, Collins LC, Allison KH, Chen YY, Jensen K, Johnson NB, Oesterreich S, Mills GB, Cherniack AD, Robertson G, Benz C, Sander C, Laird PW, Hoadley KA, King TA; TCGA Research Network, Perou CM. "Comprehensive Molecular Portraits of Invasive Lobular Breast Cancer." Cell. 2015 Oct 8;163(2):506-19. doi: 10.1016/j.cell.2015.09.033. Cancer Genome Atlas Network. "Genomic Classification of Cutaneous Melanoma." Cell. 2015 Jun 18;161(7):1681-96. doi: 10.1016/j.cell.2015.05.044. Cancer Genome Atlas Research Network, Brat DJ, Verhaak RG, Aldape KD, Yung WK, Salama SR, Cooper LA, Rheinbay E, Miller CR, Vitucci M, Morozova O, Robertson AG, Noushmehr H, Laird PW, Cherniack AD, Akbani R, Huse JT, Ciriello G, Poisson LM, Barnholtz-Sloan JS, Berger MS, Brennan C, Colen RR, Colman H, Flanders AE, Giannini C, Grifford M, Iavarone A, Jain R, Joseph I, Kim J, Kasaian K, Mikkelsen T, Murray BA, O'Neill BP, Pachter L, Parsons DW, Sougnez C, Sulman EP, Vandenberg SR, Van Meir EG, von Deimling A, Zhang H, Crain D, Lau K, Mallery D, Morris S, Paulauskis J, Penny R, Shelton T, Sherman M, Yena P, Black A, Bowen J, Dicostanzo K, Gastier-Foster J, Leraas KM, Lichtenberg TM, Pierson CR, Ramirez NC, Taylor C, Weaver S, Wise L, Zmuda E, Davidsen T, Demchok JA, Eley G, Ferguson ML, Hutter CM, Mills Shaw KR, Ozenberger BA, Sheth M, Sofia HJ, Tarnuzzer R, Wang Z, Yang L, Zenklusen JC, Ayala B, Baboud J, Chudamani S, Jensen MA, Liu J, Pihl T, Raman R, Wan Y, Wu Y, Ally A, Auman JT, Balasundaram M, Balu S, Baylin SB, Beroukhim R, Bootwalla MS, Bowlby R, Bristow CA, Brooks D, Butterfield Y, Carlsen R, Carter S, Chin L, Chu A, Chuah E, Cibulskis K, Clarke A, Coetzee SG, Dhalla N, Fennell T, Fisher S, Gabriel S, Getz G, Gibbs R, Guin R, Hadjipanayis A, Hayes DN, Hinoue T, Hoadley K, Holt RA, Hoyle AP, Jefferys SR, Jones S, Jones CD, Kucherlapati R, Lai PH, Lander E, Lee S, Lichtenstein L, Ma Y, Maglinte DT, Mahadeshwar HS, Marra MA, Mayo M, Meng S, Meyerson ML, Mieczkowski PA, Moore RA, Mose LE, Mungall AJ, Pantazi A, Parfenov M, Park PJ, Parker JS, Perou CM, Protopopov A, Ren X, Roach J, Sabedot TS, Schein J, Schumacher SE, Seidman JG, Seth S, Shen H, Simons JV, Sipahimalani P, Soloway MG, Song X, Sun H, Tabak B, Tam A, Tan D, Tang J, Thiessen N, Triche T Jr, Van Den Berg DJ, Veluvolu U, Waring S, Weisenberger DJ, Wilkerson MD, Wong T, Wu J, Xi L, Xu AW, Yang L, Zack TI, Zhang J, Aksoy BA, Arachchi H, Benz C, Bernard B, Carlin D, Cho J, DiCara D, Frazer S, Fuller GN, Gao J, Gehlenborg N, Haussler D, Heiman DI, Iype L, Jacobsen A, Ju Z, Katzman S, Kim H, Knijnenburg T, Kreisberg RB, Lawrence MS, Lee W, Leinonen K, Lin P, Ling S, Liu W, Liu Y, Liu Y, Lu Y, Mills G, Ng S, Noble MS, Paull E, Rao A, Reynolds S, Saksena G, Sanborn Z, Sander C, Schultz N, Senbabaoglu Y, Shen R, Shmulevich I, Sinha R, Stuart J, Sumer SO, Sun Y, Tasman N, Taylor BS, Voet D, Weinhold N, Weinstein JN, Yang D, Yoshihara K, Zheng S, Zhang W, Zou L, Abel T, Sadeghi S, Cohen ML, Eschbacher J, Hattab EM, Raghunathan A, Schniederjan MJ, Aziz D, Barnett G, Barrett W, Bigner DD, Boice L, Brewer C, Calatozzolo C, Campos B, Carlotti CG Jr, Chan TA, Cuppini L, Curley E, Cuzzubbo S, Devine K, DiMeco F, Duell R, Elder JB, Fehrenbach A, Finocchiaro G, Friedman W, Fulop J, Gardner J, Hermes B, Herold-Mende C, Jungk C, Kendler A, Lehman NL, Lipp E, Liu O, Mandt R, McGraw M, Mclendon R, McPherson C, Neder L, Nguyen P, Noss A, Nunziata R, Ostrom QT, Palmer C, Perin A, Pollo B, Potapov A, Potapova O, Rathmell WK, Rotin D, Scarpace L, Schilero C, Senecal K, Shimmel K, Shurkhay V, Sifri S, Singh R, Sloan AE, Smolenski K, Staugaitis SM, Steele R, Thorne L, Tirapelli DP, Unterberg A, Vallurupalli M, Wang Y, Warnick R, Williams F, Wolinsky Y, Bell S, Rosenberg M, Stewart C, Huang F, Grimsby JL, Radenbaugh AJ, Zhang J. "Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas." N Engl J Med. 2015 Jun 25;372(26):2481-98. doi: 10.1056/NEJMoa1402121. Epub 2015 Jun 10. Cancer Genome Atlas Network. "Comprehensive genomic characterization of head and neck squamous cell carcinomas." Nature. 2015 Jan 29;517(7536):576-82. doi: 10.1038/nature14129. Cancer Genome Atlas Research Network. "Integrated genomic characterization of papillary thyroid carcinoma." Cell. 2014 Oct 23;159(3):676-90. doi: 10.1016/j.cell.2014.09.050. Parfenov M, Pedamallu CS, Gehlenborg N, Freeman SS, Danilova L, Bristow CA, Lee S, Hadjipanayis AG, Ivanova EV, Wilkerson MD, Protopopov A, Yang L, Seth S, Song X, Tang J, Ren X, Zhang J, Pantazi A, Santoso N, Xu AW, Mahadeshwar H, Wheeler DA, Haddad RI, Jung J, Ojesina AI, Issaeva N, Yarbrough WG, Hayes DN, Grandis JR, El-Naggar AK, Meyerson M, Park PJ, Chin L, Seidman JG, Hammerman PS, Kucherlapati R; Cancer Genome Atlas Network. "Characterization of HPV and host genome interactions in primary head and neck cancers." Proc Natl Acad Sci U S A. 2014 Oct 28;111(43):15544-9. doi: 10.1073/pnas.1416074111. Epub 2014 Oct 13. Davis CF, Ricketts CJ, Wang M, Yang L, Cherniack AD, Shen H, Buhay C, Kang H, Kim SC, Fahey CC, Hacker KE, Bhanot G, Gordenin DA, Chu A, Gunaratne PH, Biehl M, Seth S, Kaipparettu BA, Bristow CA, Donehower LA, Wallen EM, Smith AB, Tickoo SK, Tamboli P, Reuter V, Schmidt LS, Hsieh JJ, Choueiri TK, Hakimi AA; Cancer Genome Atlas Research Network, Chin L, Meyerson M, Kucherlapati R, Park WY, Robertson AG, Laird PW, Henske EP, Kwiatkowski DJ, Park PJ, Morgan M, Shuch B, Muzny D, Wheeler DA, Linehan WM, Gibbs RA, Rathmell WK, Creighton CJ. "The somatic genomic landscape of chromophobe renal cell carcinoma." Cancer Cell. 2014 Sep 8;26(3):319-30. doi: 10.1016/j.ccr.2014.07.014. Epub 2014 Aug 21. Hoadley KA, Yau C, Wolf DM, Cherniack AD, Tamborero D, Ng S, Leiserson MD, Niu B, McLellan MD, Uzunangelov V, Zhang J, Kandoth C, Akbani R, Shen H, Omberg L, Chu A, Margolin AA, Van't Veer LJ, Lopez-Bigas N, Laird PW, Raphael BJ, Ding L, Robertson AG, Byers LA, Mills GB, Weinstein JN, Van Waes C, Chen Z, Collisson EA; Cancer Genome Atlas Research Network, Benz CC, Perou CM, Stuart JM. "Multiplatform analysis of 12 cancer types reveals molecular classification within and across tissues of origin." Cell. 2014 Aug 14;158(4):929-44. doi: 10.1016/j.cell.2014.06.049. Epub 2014 Aug 7. Cancer Genome Atlas Research Network. "Comprehensive molecular profiling of lung adenocarcinoma." Nature. 2014 Jul 31;511(7511):543-50. doi: 10.1038/nature13385. Epub 2014 Jul 9. Erratum in: Nature. 2014 Oct 9;514(7521):262. Rogers, K [corrected to Rodgers, K]. Cancer Genome Atlas Research Network. "Comprehensive molecular characterization of urothelial bladder carcinoma." Nature. 2014 Mar 20;507(7492):315-22. doi: 10.1038/nature12965. Epub 2014 Jan 29. Cancer Genome Atlas Research Network, Weinstein JN, Collisson EA, Mills GB, Shaw KR, Ozenberger BA, Ellrott K, Shmulevich I, Sander C, Stuart JM. "The Cancer Genome Atlas Pan-Cancer analysis project." Nat Genet. 2013 Oct;45(10):1113-20. doi: 10.1038/ng.2764. Cancer Genome Atlas Research Network. "Comprehensive molecular characterization of clear cell renal cell carcinoma." Nature. 2013 Jul 4;499(7456):43-9. doi: 10.1038/nature12222. Epub 2013 Jun 23. Cancer Genome Atlas Research Network, Kandoth C, Schultz N, Cherniack AD, Akbani R, Liu Y, Shen H, Robertson AG, Pashtan I, Shen R, Benz CC, Yau C, Laird PW, Ding L, Zhang W, Mills GB, Kucherlapati R, Mardis ER, Levine DA. "Integrated genomic characterization of endometrial carcinoma." Nature. 2013 May 2;497(7447):67-73. doi: 10.1038/nature12113. Erratum in: Nature. 2013 Aug 8;500(7461):242. Cancer Genome Atlas Network. "Comprehensive molecular portraits of human breast tumours." Nature. 2012 Oct 4;490(7418):61-70. doi: 10.1038/nature11412. Epub 2012 Sep 23. Cancer Genome Atlas Research Network. "Comprehensive genomic characterization of squamous cell lung cancers." Nature. 2012 Sep 27;489(7417):519-25. doi: 10.1038/nature11404. Epub 2012 Sep 9. Erratum in: Nature. 2012 Nov 8;491(7423):288. Rogers, Kristen [corrected to Rodgers, Kristen]. Cancer Genome Atlas Network. "Comprehensive molecular characterization of human colon and rectal cancer." Nature. 2012 Jul 18;487(7407):330-7. doi: 10.1038/nature11252. |
Activities: | Ultimate Frisbee: Boneyard: Masters division team. 2016 World Ultimate Champions (as US Men's Masters National Team); 2014 World Ultimate Club Champions; 2015 US National Champions; 2010, 2012, 2013 National silver medalists, 2009 Spirit of the Game award winners. Ring of Fire: Open division team, Silver medalists at 2002 UPA Championships, third place at 1998 US Nationals, fifth place at 1999 World Club Championships; Spear: Mixed-gender team, Champions at 2000 Co-ed Nationals; Blue Ridge Ultimate: Mixed-gender team finished fourth at 2002 World Club Championships; Gorilla Foot: Mixed-gender team won Spirit of the Game Award at 2005 National Championships; Alchemy: Grandmasters division team, 2015 Beach Ultimate National Champions; UNC-Chapel Hill Darkside: co-founded and captained during college, 1993-1996; Duke Women's Ultimate Frisbee Club (aka Swerve): coach, 2009-present Toro: coach, 2018 USA Ultimate: 501.(c)(3) Rules Working Group (neé Standing Rules Committee) 2000-present; officiated at 1999 and 2000 College National Championships and other tournaments; Triangle Ultimate: 501.(c)(3) Board member, 2009-2017. Other: North Carolina State Employee Credit Union (SECU): Advisory board member for Pittsboro Street, Chapel Hill branch, 2014-present. |
References available on request.
© Alan Hoyle
Last update: 2021 October 11